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LY 345899
CAS No. 10538-99-5
LY 345899 ( —— )
产品货号. M22500 CAS No. 10538-99-5
LY 345899 是一种叶酸类似物，也是一种亚甲基四氢叶酸脱氢酶和 MTHFD2 抑制剂（IC50 分别为 96 nM 和 663 nM，对于 MTHFD1，Ki 为 18 nM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3021 | 有现货 |
|
| 10MG | ￥4504 | 有现货 |
|
| 25MG | ￥7233 | 有现货 |
|
| 50MG | ￥9882 | 有现货 |
|
| 100MG | ￥13203 | 有现货 |
|
| 500MG | ￥26568 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称LY 345899
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述LY 345899 是一种叶酸类似物，也是一种亚甲基四氢叶酸脱氢酶和 MTHFD2 抑制剂（IC50 分别为 96 nM 和 663 nM，对于 MTHFD1，Ki 为 18 nM）。
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产品描述LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).
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体外实验LY 345899 could suppress the MTHFD enzyme in the cytoplasm and mitochondria.LY 345899 could disturb the NADPH and redox homeostases and accelerate cell death under oxidative stress, such as hypoxia, or causing in vitro anchorage independence and in vivo impaired tumor growth and metastasis.
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体内实验LY345899 (Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks) shows potent antitumor activity and displays therapeutic activity against CRC in vivo. Animal Model:SW620 or PDX-based BABL/c nude colorectal cancer (CRC) model Dosage:5-10 mg/kg Administration:Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks Result:Displayed lower cell proliferation indices and higher cell apoptosis.Exhibited no statistically significant weight loss or other signs of acute or delayed toxicity in mice.
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同义词——
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通路Others
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靶点Other Targets
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受体MTHFD1
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研究领域——
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适应症——
化学信息
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CAS Number10538-99-5
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分子量471.42
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分子式C20H21N7O7
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纯度>98% (HPLC)
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溶解度DMSO:125 mg/mL (265.16 mM; Need ultrasonic)
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SMILESNc1nc(=O)c2N3C(CN(C3=O)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2[nH]1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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γ-2-MSH (41-58), ami...
Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor. It induces a sustained increase in intracellular free calcium levels ([Ca2+]i) in a subpopulation of pituitary cells. Most of the cells responding to 3-MSH express more than one pituitary hormone mRNA. The effect of 3-MSH is blocked by SHU9119, a MC3R and MC4R antagonist, in only 50% of the responsive cells, suggesting that in half of these cells the mediating receptor is not the MC3R. Low picomolar doses of 3-MSH increase [Ca2+]i in the growth hormone (GH)- and prolactin (PRL)-secreting GH3 cell line.
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Biotin-C5-amino-C5-a...
Biotin-C5-amino-C5-amino 是一种基于烷基链的 PROTAC 连接体，可用于 PROTAC 的合成。
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D-Saccharic acid pot...
D-糖酸钾盐是一种由氧化糖形成的化合物，可用于测试肝酶诱导的存在。研究表明，D-葡萄糖醛酸内酯脱氢酶将 D-糖酸钾盐氧化成 D-葡萄糖醛酸-1,4;6,3-二内酯。
